Abstract
We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.
Publication types
-
Case Reports
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Aged, 80 and over
-
Antifungal Agents / pharmacology*
-
Candida tropicalis* / drug effects
-
Candida tropicalis* / genetics
-
Candida tropicalis* / isolation & purification
-
Candidiasis / microbiology
-
Candidiasis / prevention & control*
-
Caspofungin
-
Drug Resistance, Fungal
-
Echinocandins / pharmacology*
-
Fungemia / microbiology
-
Fungemia / prevention & control*
-
Hematologic Neoplasms / complications
-
Hematologic Neoplasms / drug therapy*
-
Hematologic Neoplasms / microbiology*
-
Humans
-
Lipopeptides
-
Male
-
Middle Aged
Substances
-
Antifungal Agents
-
Echinocandins
-
Lipopeptides
-
Caspofungin